Associate Certified Entomologist (ACE) Practice Exam

What is the MOA for anthranilic diamides?

1. Interfere with protein synthesis

2. Disrupt ryanodine receptors

3. Block neurotransmitter action

4. Inhibit lipid synthesis

The correct answer is: Disrupt ryanodine receptors

The mechanism of action (MOA) for anthranilic diamides is primarily to disrupt ryanodine receptors. This class of insecticides works by targeting the calcium release channels in the muscle cells of insects. By interfering with the function of these receptors, anthranilic diamides cause uncontrolled release of calcium ions, leading to paralysis and eventual death of the insect. This mechanism is particularly unique and effective for controlling various pests because it specifically affects muscle contraction, causing severe muscle spasms, which are lethal to the insects. This selective action also makes them less harmful to non-target organisms, which rely on different physiological pathways. The other options suggest different mechanisms that do not align with how anthranilic diamides operate. For example, protein synthesis interference primarily relates to other insecticide classes like insect growth regulators, whereas neurotransmitter blockade pertains to different insecticides that target neural pathways. Inhibition of lipid synthesis is not relevant to the action of anthranilic diamides but rather relates to other metabolic targets in certain pests. Thus, understanding the specific action of disrupting ryanodine receptors helps clarify the unique role of anthranilic diamides in pest management strategies.